Carcinoma of Unknown Primary: Diagnostic Approaches for Radiologists
Carcinoma of unknown primary is an important and complex disease entity that presents challenges to interpreting radiologists. This article presents a comprehensive clinical, pathologic, and radiologic work-up and assessment for radiologists. It is important for the radiologist to know
the p16, high-risk human papilloma virus, and Epstein-Barr virus status; nodal drainage patterns of head and neck squamous cell carcinoma; and the utility of various imaging modalities to help identify the primary site and guide therapy.
Learning Objectives: To understand the clinical, pathologic, and radiologic evaluation of carcinoma of unknown primary (CUP); to provide an overview of the clinical and pathologic work-up for CUP that aids in imaging interpretation; and to recognize patterns of nodal involvement for identification of the primary disease
Learning Objectives: To understand the clinical, pathologic, and radiologic evaluation of carcinoma of unknown primary (CUP); to provide an overview of the clinical and pathologic work-up for CUP that aids in imaging interpretation; and to recognize patterns of nodal involvement for identification of the primary disease
Keywords: AJCC = American Joint Committee for Cancer; CECT = contrast-enhanced CT; CUP = carcinoma of unknown primary; EBV = Epstein-Barr virus; FNA = fine-needle aspiration; HNSCC = head and neck squamous cell carcinoma; HPV = human papilloma virus; ISH = in situ hybridization; NPC = nasopharyngeal carcinoma; OPSCC = oropharyngeal squamous cell carcinoma; PCR = polymerase chain reaction; SCC = squamous cell carcinoma; hr-HPV = high-risk human papilloma virus
Document Type: Research Article
Publication date: January 1, 2023
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