Prionopathies and Prionlike Protein Aberrations in Neurodegenerative Diseases
Learning Objective: Upon completion of this article, one should be able to describe the various types of prion diseases, recognize and identify the common the neuro-imaging findings in prion diseases, describe seeding mechanism of prion disease, list the common amyloid PET tracers used for Alzheimer’s disease, and list common imaging biomarkers in neurodegenerative diseases.
Keywords: AD = Alzheimer disease; Aβ = amyloid beta; CJD = Creutzfeldt-Jakob disease; EEG = electroencephalogram; FFI = fatal familial insomnia; GSS = Gerstmann-Sträussler-Scheinker; HD = Huntington disease; IRB = institutional review board; M-M = methionine-methionine; M-V = methionine-valine; ND = neurodegenerative disease; PD = Parkinson disease; PrPSc = abnormal prion scrapie protein; PrPc = normal prion protein; RT-QuIC = real-time quaking-induced conversion assay; V-V = valine-valine; VPSPr = variably protease-sensitive prionopathy; iCJD=iatrogenic Creutzfeldt-Jakob disease; sCJD = sporadic Creutzfeldt-Jakob disease; vCJD = variant Creutzfeldt-Jakob disease; α-syn = alpha-synuclein
Document Type: Research Article
Publication date: March 1, 2021
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