Anti-LGI1 Encephalitis: A Case Report of a Recently Described Disease Entity

Anti-leucine-rich glioma-inactivated protein 1 encephalitis is a rare disease characterized by autoantibodies to a secreted synaptic protein associated with the voltage-gated potassium channel complex and previously attributed to voltage-gated potassium channel antibodies. The classic clinical presentation is limbic encephalitis with memory loss and pathognomonic faciobrachial dystonic seizures, but patients can also experience paroxysmal dizziness, as well as pain and other symptoms of peripheral nervous system involvement. We present a case of anti‐leucine-rich glioma-inactivated protein 1 encephalitis as a review of the clinical presentation, laboratory findings, and imaging findings, and discuss prognosis with treatment. A brief review of the anti‐leucine-rich glioma-inactivated protein 1 encephalitis literature is also provided.