John Cunningham Virus‐induced Cerebellar Granular Cell Neuronopathy in a Patient With MS Treated With Natalizumab
We described a case of John Cunningham virus‐induced granule cell neuronopathy in a 36-year-old patient with multiple sclerosis (MS) who was treated with natalizumab for 6 years. This patient developed progressive cerebellar syndrome. Within 6 months, 3 successive MRIs with DWI
disclosed rapidly progressive cerebellar atrophy with cortical cerebellar signal intensity abnormalities, including high signal intensity on DWI with mildly decreased ADC values. This report highlighted the importance of detecting the early MR features of John Cunningham virus neuronopathy
in a patient with MS who was treated with natalizumab and who had recent-onset cerebellar syndrome.
Keywords: ADC = apparent diffusion coefficient; CSF = cerebrospinal fluid; DWI = diffusion-weighted imaging; FLAIR = fluid attenuated inversion recovery; JCV = John Cunningham virus; MS = multiple sclerosis; T2WI = T2-weighted imaging
Document Type: Research Article
Publication date: November 1, 2016
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