Skip to main content

Free Content Diffusion Tensor Tractography for Understanding Complex Brain Fiber Connectivity in Holoprosencephaly: A Unique Case Presentation

Holoprosencephaly is the most common developmental disorder of the prosencephalon. We present a case of alobar holoprosencephaly with cortical migration anomalies, a large midline mass, a monooptic nerve, and no dorsal cyst. Diffusion tensor tractography showed markedly abnormal supratentorial and posterior fossa white matter fibers, along with an enlarged hippocampal commissure across the dorsal midline cerebrum and a monooptic nerve projecting toward the cerebellum. Fiber tracking revealed information about white matter composition and organization not evident with conventional MR imaging.

Keywords: DTI = diffusion tensor imaging; DTT = diffusion tensor tractography; HPE = holoprosencephaly; MR = magnetic resonance; SHH = sonic hedgehog

Document Type: Research Article

Publication date: September 1, 2015

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content