@article {Nguyen:2025:2637-8329:192,
title = "Distinguishing Optic Neuritis and Optic Perineuritis: A Pictorial Review",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2025",
volume = "15",
number = "3",
publication date ="2025-07-01T00:00:00",
pages = "192-206",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2025/00000015/00000003/art00005",
doi = "doi:10.3174/ng.2400072",
keyword = "NMOSD = neuromyelitis optica spectrum disorder, A-PION = arteritic posterior ischemic optic neuropathy, IOIS = idiopathic orbital inflammatory syndrome, CRION = chronic relapsing inflammatory optic neuropathy, A-AION = arteritic anterior ischemic optic neuropathy, OPG = optic pathway glioma, BD = Neuro-Behçet disease, AQP4 = aquaporin 4, ANCA = antineutrophilic cytoplasmic antibodies, NMO = neuromyelitis optica, RAPD = relative afferent pupillary defect, AION = anterior ischemic optic neuropathy, PION = posterior ischemic optic neuropathy, GCA = giant cell arteritis, ON = optic neuritis, MOGAD = myelin oligodendrocyte glycoprotein antibody disease, AAV = ANCA-associated vasculitis, OPN = optic perineuritis, MPO-ANCA = myeloperoxidase ANCA, GPA = granulomatosis with polyangiitis, PR3-ANCA = proteinase-3 antineutrophilic cytoplasmic antibodies, RION = radiation-induced optic neuropathy, MS = multiple sclerosis, LEON = longitudinally extensive optic neuritis",
author = "Nguyen, A.D. and Rayasam, K. and Kaimal, G. and Ozgur, H. and Rogers, S.",
abstract = "Both optic neuritis (ON) and optic perineuritis (OPN) are distinct entities with the idiopathic forms having different clinical presentations, imaging appearances, and treatment courses. Additionally, they are both associated with different diseases, each with different underlying pathophysiology
and appropriate management. ON is associated with multiple sclerosis, neuromyelitis optica, and myelin oligodendrocyte glycoprotein antibodyassociated disease. OPN is associated with giant cell arteritis and infectious neuritis. In this article, we review these common entities, their
etiologies, imaging appearance, mimics, and lesser known vasculitis and rheumatologic associations, to ultimately provide a comprehensive review on ON and OPN.Learning Objective: To describe the distinguishing imaging characteristics of both ON and OPN.",
}