@article {Gonçalves:2024:2637-8329:81,
title = "What is Under the Tent? Posterior Fossa Tumors in Children, the Usual SuspectsPart 1",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2024",
volume = "14",
number = "2",
publication date ="2024-04-01T00:00:00",
pages = "81-94",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2024/00000014/00000002/art00001",
doi = "doi:10.3174/ng.2300018",
keyword = "PFT = posterior fossa tumor, BRAF = B-Raf Proto-Oncogene, Serine/Threonine Kinase, ATRT = atypical teratoid/rhabdoid tumor, SPACE = Sampling Perfection with Application optimized Contrast using different flip angle Evolution, DCE = dynamic contrast enhancement, ETMR = embryonal tumor with multilayered rosettes, CBTRUS = Central Brain Tumor Registry of the United States, PF = posterior fossa, DMG = diffuse midline glioma, ASL = arterial spin-labeling, SHH = sonic hedgehog-activated, WNT = wingless, PA = pilocytic astrocytoma, VISTA = Volume Isotropic Turbo Spin Echo Acquisition, DIPG = diffuse intrinsic pontine glioma, WHO = World Health Organization, MAPK = mitogen-activated protein kinase, DLGT = diffuse leptomeningeal glioneuronal tumor, TP53 = Tumor Protein p53",
author = "Gon{\c{c}}alves, Fabricio G. and Mahecha-Carvajal, M. E. and Tierradentro-Garcia, L. O. and Oliveira, V. V. and Viaene, A. N. and Bag, A. K. and Andronikou, S. and Vossough, A.",
abstract = "Pediatric posterior fossa tumors are a major cause of morbidity and mortality in children. In this 2-part series, we discuss the spectrum of posterior fossa tumors and their clinical and molecular characteristics. In Part 1, the authors discuss the 5 primary differential diagnoses of
posterior fossa tumors: medulloblastoma, pilocytic astrocytoma, ependymoma, diffuse midline glioma, H3K27-altered, and atypical teratoid/rhabdoid tumors. Each posterior fossa tumor is clinically and histologically defined. Additionally, relevant epidemiology data, current genetics/molecular
classification according to the fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System, and imaging findings are reviewed. The new version of the international standard for the classification of central nervous system tumors introduces
major changes that advance the role of molecular diagnostics in the pediatric central nervous system tumor classification, particularly in posterior fossa tumors, which may impact management and outcomes.Learning Objective: To recognize the imaging appearance of the most common posterior
fossa tumors in children.",
}