@article {Majumdar:2024:2637-8329:66,
title = "MR ImagingGuided High Intensity Focused Ultrasound in the Treatment of Neurologic Disease: Current Applications and Future Directions",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2024",
volume = "14",
number = "1",
publication date ="2024-02-01T00:00:00",
pages = "66-80",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2024/00000014/00000001/art00007",
doi = "doi:10.3174/ng.2200035",
keyword = "OCD = obsessive compulsive disorder, CRST = Clinical Rating Scale for Tremor, STN = subthalamic nucleus, RNS = responsive neurostimulation, MRgFUS = MR imaging‐guided focused ultrasound, DBS = deep brain stimulation, PC = posterior commissure, PD = Parkinson disease, GPi = globus pallidus interna, UPDRS = Unified Parkinson’s Disease Rating Scale, CLp = posterior central lateral nucleus, GDNF = glial-derived neurotrophic factor, FUS = focused ultrasound, HIFU = high-intensity focused ultrasound, PSA = posterior subthalamic area, MTLE = mesial temporal lobe epilepsy, ET = essential tremor, VIM = ventral intermediate nucleus of the thalamus, CLT = central lateral thalamotomy",
author = "Majumdar, S. and Yang, S.K. and Salamon, N.",
abstract = "MR imagingguided focused ultrasound is a revolutionary noninvasive technique with a wide breadth of clinical potential. MR imagingguided focused ultrasound uses focused ultrasound energy delivered transcranially to treat a variety of neurologic disease processes. High-intensity
focused ultrasound creates sufficient acoustic energy for targeted noninvasive thermal ablation of intracranial soft tissues, with sharply marginated treatment zones overall superior to the established percutaneous ablation techniques. The use of concurrent MR imaging allows highly accurate
spatial and thermal guidance, with fine anatomic detail, high soft-tissue contrast, and real-time monitoring of the treatment zone. Here we review the current established applications of MR imagingguided focused ultrasound in the treatment of neurologic disease and the relevant anatomic
targets for each discussed disease entity, with a focus on essential tremor, Parkinson disease, and neuropathic pain, along with investigative applications and future directions related to this innovative technology.Learning Objective: To provide a comprehensive review of the existing
literature on current neurologic applications of MR imagingguided high-intensity focused ultrasound and the relevant anatomic targets for each disease entity, discuss investigative applications and future directions for MR imagingguided high-intensity focused ultrasound, and
increase awareness among providers to promote safe informed use of this relatively newer technology",
}