@article {Junn:2023:2637-8329:20,
title = "Carcinoma of Unknown Primary: Diagnostic Approaches for Radiologists",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2023",
volume = "13",
number = "1",
publication date ="2023-01-01T00:00:00",
pages = "20-26",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2023/00000013/00000001/art00003",
doi = "doi:10.3174/ng.2100031",
keyword = "SCC = squamous cell carcinoma, CECT = contrast-enhanced CT, NPC = nasopharyngeal carcinoma, AJCC = American Joint Committee for Cancer, HPV = human papilloma virus, PCR = polymerase chain reaction, FNA = fine-needle aspiration, hr-HPV = high-risk human papilloma virus, EBV = Epstein-Barr virus, ISH = in situ hybridization, OPSCC = oropharyngeal squamous cell carcinoma, CUP = carcinoma of unknown primary, HNSCC = head and neck squamous cell carcinoma",
author = "Junn, J.C. and Soderlund, K.A. and Glastonbury, C.M.",
abstract = "Carcinoma of unknown primary is an important and complex disease entity that presents challenges to interpreting radiologists. This article presents a comprehensive clinical, pathologic, and radiologic work-up and assessment for radiologists. It is important for the radiologist to know
the p16, high-risk human papilloma virus, and Epstein-Barr virus status; nodal drainage patterns of head and neck squamous cell carcinoma; and the utility of various imaging modalities to help identify the primary site and guide therapy.Learning Objectives: To understand the clinical,
pathologic, and radiologic evaluation of carcinoma of unknown primary (CUP); to provide an overview of the clinical and pathologic work-up for CUP that aids in imaging interpretation; and to recognize patterns of nodal involvement for identification of the primary disease",
}