@article {Currie:2022:2637-8329:43,
title = "A Comprehensive Clinical Review of Adult-Type Diffuse Glioma Incorporating the 2021 World Health Organization Classification",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2022",
volume = "12",
number = "2",
publication date ="2022-04-01T00:00:00",
pages = "43-70",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2022/00000012/00000002/art00001",
doi = "doi:10.3174/ng.2100034",
keyword = "PI3K = phosphoinositide 3-kinase, AKT= AK strain transforming (known as protein kinase B), Raf = rapidly accelerated fibrosarcoma, a signaling protein, GSC = glioma stem cells, MDM2 = mouse double minute 2 homolog, MGMT = methyltransferase, pRB = retinoblastoma protein, EGF = epidermal growth factor, EGFR = epidermal growth factor receptor, WHO = World Health Organization, RTK = receptor tyrosine kinase, Ras = rat sarcoma virus, a signaling protein, GBM = glioblastoma, LGG = low-grade glioma, ECM = extracellular matrix, VEGF = vascular endothelial growth factor, ISF = interstitial fluid, IDHm = IDH mutation, TMZ = temozolomide, BTB = blood-tumor barrier, PTEN = phosphatase and tensin homolog, TME = tumor microenvironment, ALT = alternative lengthening of telomeres, T1Gd = intravenous gadolinium contrast administration, NSC = neural stem cell, HGG = high-grade glioma, mTOR = mammalian/mechanistic target of rapamycin, PDGFR = platelet derived growth factor receptor, cIMPACT = Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy, HG = hydroxyglutarate, TCGA = The Cancer Genome Atlas, IDHwt = IDH wild type, OS = overall survival, ATP = adenosine triphosphate, ISS = interstitial system, IDH = isocitrate dehydrogenase, CDK = cyclin-dependent kinase",
author = "Currie, S. and Fatania, K. and Matthew, R. and Wurdak, H. and Chakrabarty, A. and Murray, L. and Short, S.",
abstract = "The intent of this article is to provide a comprehensive, educational review of adult-type diffuse gliomas, bringing together the role of the multidisciplinary team and giving the reader biologic, surgical, radiologic, and oncologic insight into these tumors. The reader will be guided
through subsections that explain the molecular pathophysiology, diagnosis, treatment, prognosis and natural history of the disease. The 2021 World Health Organization Classification will be explained through a combination of concise historic review of glioma diagnosis and contemporary knowledge
of the molecular pathways. Accompanying illustrations will act as powerful tools for comprehension. These concepts will be underpinned by frequent reference to neuroradiology and a grounding of normal brain composition.Learning Objective: To understand the pathophysiologic concepts that
underly the World Health Organization Classification and natural history of adult-type diffuse gliomas and how these relate to imaging and treatment strategies",
}