Large Eyes and Small Eyes: An Overview of Globe Abnormalities in the Neonate and Infant

There is a wide range of pathologies that may be seen in the globe of the neonate and the infant. An appropriate differential diagnosis can be formulated on the basis of the size of the globe. Additional key features can further narrow the differential considerations and may be characteristic of a particular diagnosis. This review provides an overview of how imaging differentiates diseases of the globe. A brief review of prognosis and treatment of conditions that involve the globe is also provided. Knowledge and differentiation of globe pathologies are essential due to the potential for irreversible damage to vision and to provide accurate prognoses for families.

Learning Objective: To recognize the wide range of pathologies that may be seen in the globe of the neonate and the infant, and to identify how key features, including the size of the globe, can narrow the differential diagnosis.