@article {Riley:2018:2637-8329:234,
title = "Subcortical U-Fibers: Signposts to the Diagnosis of White Matter Disease",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2018",
volume = "8",
number = "4",
publication date ="2018-08-01T00:00:00",
pages = "234-243",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2018/00000008/00000004/art00001",
doi = "doi:10.3174/ng.1700048",
keyword = "FLAIR = fluid-attenuated inversion recovery, ADEM = acute disseminated encephalomyelitis, CADASIL = cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, PML = progressive multifocal leukoencephalopathy, MS = multiple sclerosis, PRES = posterior reversible encephalopathy syndrome",
author = "Riley, K.J. and O'Neill, D.P. and Kralik, S.F.",
abstract = "White matter diseases can be broadly separated into 3 main categories: diseases that affect myelin metabolism, diseases that result in direct damage to myelin and/or oligodendrocytes, and vascular diseases. Disorders of myelin metabolism (dysmyelinating disorders), including many inherited
leukodystrophies, will generally spare the subcortical U-fibers, with their relatively slower rate of myelin turnover. However, conditions in which direct damage to previously normal myelin and/or oligodendrocytes predominates (demyelinating disorders), including multiple sclerosis and progressive
multifocal leukoencephalopathy, typically demonstrate early U-fiber involvement. The purpose of this article is to demonstrate how recognizing the presence or absence of subcortical U-fiber involvement as a visible manifestation of the underlying pathophysiology in white matter disease can
be extremely helpful in more confidently narrowing what may otherwise be a very broad differential diagnosis.Learning Objective: To recognize how the presence or absence of subcortical U-fiber involvement in white matter disease can help narrow what may otherwise be a very broad differential
diagnosis.",
}