@article {Som:2018:2637-8329:56,
title = "Embryogenesis of the Olfactory System: Part I: Embryogenesis of the Olfactory Nasal Mucosa and the Olfactory Bulb",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2018",
volume = "8",
number = "1",
publication date ="2018-02-01T00:00:00",
pages = "56-66",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2018/00000008/00000001/art00008",
doi = "doi:10.3174/ng.1700002",
keyword = "EGF = epidermal growth factor, cAMP = cyclic adenosine monophosphate, EMX2 = homolog of the Drosophila empty spiracles gene (it is a transcription factor that helps pattern the brain), SHH = sonic hedgehog protein, BMP = bone morphogenetic protein (BMP 2,4,7), iNOS = nitric oxide synthase, WNT = gene family that presently consists of 19 genes that make ligands that are signaling molecules prominent in many areas of embryogenesis (WNT 1‐19), LIF = leukemia inhibitory factor, OCT1 = octamer transcription factor, a stress sensor, CADHERIN = calcium-dependent adhesion proteins are a class of type 1 transmembrane proteins (they play roles in cell adhesion, and they are calcium ion dependent), COUP-TF1 = chicken ovalbumin upstream promotor transcription factor 1 (a nuclear hormone receptor), GDF-11 = growth differentiation factor 11, SEMA3A = semaphorin 3a, whose proteins can be chemoattractive or chemorepulsive to apical dendrites, FGF = fibroblast growth factor(s) (FGF8 is one of these factors), TENASCIN-C = a glycoprotein that is expressed in the extracellular matrix; it plays a role in restricting neurogenic areas of the central nervous system, ACTIVINβB = protein complex involved in cell proliferation and differentiation, ORN = olfactory receptor neuron, HGF = hepatocyte growth factor, RA = retinoic acid, PAX = a group of paired box gene transcription factors, including PAX 6 and 7, NO = nitric oxide, SOX2 = sex-determined region Y-box is a neural-inducing homeobox gene, IGF-I = insulin growth factor I, SLIT1, SLIT2 = Slit homolog 1 and 2 genes, guidance molecules, Neuropilin = neuropilins are multifunctional non‐tyrosine kinase receptors that play a key role in mediating axonal guidance in the developing nervous system",
author = "Som, P.M. and Naidich, T.P.",
abstract = "Olfaction is the oldest of human senses. It is the only sense in which sensory neurons project outside the calvaria to detect sensory signals. It is the only sense that transmits information directly to the oldest portion of the human brain (the paleocortex) without any intervening
thalamic relay. It is the single sense generated and supported by the largest family of genes. The olfactory system develops as a coordinated interaction between the ingrowth of olfactory sensory neurons from the olfactory epithelium of the nose and the outgrowth of the olfactory diverticulum
from the frontal lobe. It is supported by continual, lifelong replenishment of the system by olfactory progenitor neurons of the nose and progenitor interneurons from the subventricular zone of the brain.Learning Objective: To understand more completely the development of the peripheral
portion of the olfactory system.",
}