@article {Wahab:2018:2637-8329:7, title = "A Case of Immune Reconstitution Inflammatorylike Syndrome in a Patient with Multiple Sclerosis Secondary to Discontinuation of Fingolimod", journal = "Neurographics", parent_itemid = "infobike://asnr/ng", publishercode ="asnr", year = "2018", volume = "8", number = "1", publication date ="2018-02-01T00:00:00", pages = "7-11", itemtype = "ARTICLE", issn = "2637-8329", eissn = "2637-8329", url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2018/00000008/00000001/art00002", doi = "doi:10.3174/ng.9170221", keyword = "IFNB = interferon B, JCV = John Cunningham virus, EDSS = expanded disability status scale, PML = progressive multifocal leukoencephalopathy, IRIS = immune reconstitution inflammatory syndrome", author = "Wahab, W.A. and Lee, L. and Aviv, R.", abstract = "We reported a case of a 41-year-old man with MS who was initially treated with fingolimod, but this treatment was stopped when the patient declined neurologically with associated lymphopenia. After medication discontinuation, the patient's clinical condition worsened dramatically. MR imaging findings demonstrated significant changes consistent with an immune reconstitution inflammatorylike syndrome. The purpose of this case report was to increase awareness of this rarely reported condition with fingolimod withdrawal in patients with MS.", }