@article {Meoded:2017:2637-8329:243,
title = "Diffusion Tensor Imaging and Fiber Tractography of Pediatric Posterior Fossa Malformations",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2017",
volume = "7",
number = "4",
publication date ="2017-07-01T00:00:00",
pages = "243-261",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2017/00000007/00000004/art00001",
doi = "doi:10.3174/ng.9170208",
keyword = "TPF = transverse pontine fiber, AD = axial diffusivity, CST = corticospinal tract, RD = radial diffusivity, TR = repetition time, PCH = pontocerebellar hypoplasia, SCP = superior cerebellar peduncle, FOV = field of view, JS = Joubert syndrome, ICP = inferior cerebellar peduncle, FA = fractional anisotropy, CSF = cerebrospinal fluid, FT = fiber tractography, DEC = directionally encoded color, CI = Chiari type I malformation, 2D = 2 dimensional, CIII = Chiari type III malformation, MD = mean diffusivity, MR = magnetic resonance, TE = echo time, CII = Chiari type II malformation, PTCD = pontine tegmental cap dysplasia, ADC = apparent diffusion coefficient, DWM = Dandy-Walker malformation, 3D = 3 dimensional, DTI = diffusion tensor imaging, FLAIR = fluid attenuated inversion recovery, MCP = middle cerebellar peduncle, ML = medial lemniscus, DWI = diffusion weighted imaging",
author = "Meoded, A. and Bosemani, T. and Boltshauser, E. and Scheer, I. and Huisman, T.A.G.M. and Poretti, A.",
abstract = "Diffusion tensor imaging (DTI) is an advanced MR imaging technique that provides noninvasive qualitative and quantitative information about the white matter microarchitecture. DTI and fiber tractography have been increasingly used in the past decade to investigate the microstructural
neuroarchitecture of posterior fossa malformations. This article aimed to review DTI and fiber tractography findings in several posterior fossa malformations, and highlighted the added value of DTI and fiber tractography compared with conventional MR imaging. DTI and fiber tractography may
provide information that is helpful to better understand the pathogenesis of selected posterior fossa malformations. In addition, DTI may elucidate the anatomic role of the cerebellum for neurocognitive functions in children with posterior fossa malformations and DTI scalars of the cerebellar,
and brain stem white matter tracts may serve as a predictive biomarker for cognitive outcome. Finally, quantitative DTI analysis of cerebellar and brain stem white matter tracts may help to select candidates for therapeutic interventions and may enable monitoring of the therapy response.Learning
Objective: To recognize the utility of diffusion tensor imaging and fiber tractography to study malformations of the posterior fossa and highlight the additional information that diffusion tensor imaging and fiber tractography may provide compared with conventional MR imaging sequences.",
}