@article {McCollister:2015:2637-8329:96,
title = "Inverted Papilloma: A Review and What's New",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2015",
volume = "5",
number = "3",
publication date ="2015-05-01T00:00:00",
pages = "96-103",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2015/00000005/00000003/art00002",
doi = "doi:10.3174/ng.3150117",
keyword = "IPap = inverted papilloma, EBV = Epstein Barr virus, SCCa = squamous cell carcinoma, HPV = human papilloma virus",
author = "McCollister, K.B. and Hopper, B.D. and Ginsberg, L.E. and Michel, M.A.",
abstract = "Although inverted papilloma (IPap) is a rare neoplasm, it is of considerable interest as it can be locally aggressive, has a high rate of recurrence, and is associated with malignancy. The name inverted refers to the histology of the lesion as there is invagination of
hyperplastic epithelium into the underlying stroma. The pathogenesis of IPap is unclear and associations with inflammation, noxious agents, and human papilloma virus (HPV) have been proposed. Synchronous or metachronous malignancy is reported in 5%15% of cases, with squamous cell carcinoma
being the most common associated malignancy. Imaging plays an important role in differentiating IPap from other lesions (polyps), detecting coexistent malignancy, guiding the surgeon for the appropriate surgical approach, and detecting recurrences. It is important to identify the point of
attachment of the lesion to the nasal cavity wall or sinus wall, as incomplete resection can result in recurrence. The characteristic MR appearance of IPap is a convoluted, cerebriform pattern that correlates with the lesion's histology. The treatment of choice is complete surgical resection
and the approach used depends upon the location of tumor attachment and extent of the lesion. Endonasal endoscopic, limited external, radical external, and combined endoscopic-external approaches may be used. Long-term follow-up is recommended to detect late recurrences and metachronous multifocal
disease.Learning Objective: Understand the epidemiology of inverted papilloma and research with respect to HPV, the role of imaging and distinctive imaging features of inverted papilloma, and current treatment approaches for inverted papilloma.",
}