@article {Som:2013:2637-8329:169, title = "Development of the Skull Base and Calvarium: An Overview of the Progression from Mesenchyme to Chondrification to Ossification", journal = "Neurographics", parent_itemid = "infobike://asnr/ng", publishercode ="asnr", year = "2013", volume = "3", number = "4", publication date ="2013-12-01T00:00:00", pages = "169-184", itemtype = "ARTICLE", issn = "2637-8329", eissn = "2637-8329", url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2013/00000003/00000004/art00003", doi = "doi:10.3174/ng.4130069", keyword = "FGFR = fibroblast growth factor receptors, TGF = transforming growth factors", author = "Som, P.M. and Naidich, T.P.", abstract = "The development of the calvaria, skull base, and facial bones proceeds in an orderly fashion from a mesenchymal anlage, through chondrification, and finally to ossification. This review presents a current overview of the overall process, illustrated with multiple drawings to help make clearer the complex developmental changes that occur.Learning Objective: List 5 specific events during embryologic development of the skull base that impact the imaging appearance of pediatric and adult skull base pathology.", }