@article {Kennedy:2012:2637-8329:2,
title = "Post-Transplantation Lymphoproliferative Disorder of the Central Nervous System: Spectrum of Imaging Findings",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2012",
volume = "2",
number = "1",
publication date ="2012-03-01T00:00:00",
pages = "2-12",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2012/00000002/00000001/art00002",
doi = "doi:10.3174/ng.1120019",
keyword = "ADC = apparent diffusion coefficient, DWI = diffusion weighted imaging, PTLD = post-transplantation lymphoproliferative disorder, PRES = posterior reversible encephalopathy syndrome, AIDS = acquired immune deficiency syndrome, EBV = Epstein-Barr virus, FLAIR = fluid-attenuated inversion recovery, CNS = central nervous system, PCNSL = primary CNS lymphoma, CMV = cytomegalovirus, HSV = herpes simplex virus, PML = progressive multifocal leukoencephalopathy, HIV = human immunodeficiency virus, FDG PET = fluorodeoxyglucose positron emission tomography",
author = "Kennedy, Tabassum A. and Lubner, Meghan G. and Lake, Wendell and Salamat, M. Shahriar and Gentry, Lindell R. and Baskaya, Mustafa K.",
abstract = "PTLD is a rare but known complication after organ transplantation. It represents a spectrum of diseases, ranging from premalignant lymphoid hyperplasia to aggressive lymphoma. The distribution of PTLD is dependent on several risk factors, including the type of organ transplantation,
the intensity of immunosuppressive therapy, and the age of the patient. PTLD involving the CNS often occurs in isolation and is not typically associated with systemic involvement of PTLD. The imaging and pathologic features of CNS PTLD are similar to those of PCNSL, seen in patients with HIV.
Several imaging patterns associated with CNS PTLD include 1 peripherally enhancing intraparenchymal masses and nodular leptomeningeal enhancement. Imaging plays a crucial role in disease diagnosis, guiding biopsy and monitoring disease response following therapy. The purpose of this pictorial
essay is to review the pathologic features of CNS PTLD and to illustrate the spectrum of imaging findings of CNS PTLD with a variety of case examples.",
}