@article {Booth:2011:2637-8329:108,
title = "Neuro-Oncology Single-Photon Emission CT: A Current Overview",
journal = "Neurographics",
parent_itemid = "infobike://asnr/ng",
publishercode ="asnr",
year = "2011",
volume = "1",
number = "3",
publication date ="2011-12-01T00:00:00",
pages = "108-120",
itemtype = "ARTICLE",
issn = "2637-8329",
eissn = "2637-8329",
url = "https://asnr.publisher.ingentaconnect.com/content/asnr/ng/2011/00000001/00000003/art00005",
doi = "doi:10.3174/ng.3110014",
keyword = "rCBV = relative cerebral blood volume, LGG = low-grade glioma, 123IMT = iodine-123-α-methyl tyrosine, DTPA = diethylenetriamine pentaacetic acid, 99mTc = technetium 99m, Cho = choline, 111In = indium 111, MIBI = hexakis-2-methoxyisobutyl isonitrile, 201Tl = thallium 201, ROI = region of interest, BBB = blood brain barrier, 18FET = O-(2-[18F]fluoroethyl)-l-tyrosine, 18F = fluorine 18, Cr = creatine, SPECT = single-photon emission CT, HMPAO = hexamethypropyleneamine oxime, HGG = high-grade glioma, SRS = somatostatin receptor scintigraphy, NAA = N-acetyl aspartate, TF = 1,2-bis[bis(2-ethoxyethyl)phospino] ethane, GLUT = glucose transporter, ATPase = adenosine triphosphatase, 201Pb = lead 201, PCV = procarbazine, lomustine, and vincristine, 18FDG = 18F-fluorodeoxyglucose, PET = positron-emission tomography, Na+/K+ = sodium/potassium, 123I = iodine 123, 201Hg = mercury 201, GBM = glioblastoma multiforme, 123IPA = p-[(123)I]-iodo-L-phenylalanine, TI = thallium index, ADC = apparent diffusion coefficient, MRS = MR spectroscopy, 11C MET = L-methyl-11C methionine, MRSI = MR spectroscopic imaging",
author = "Booth, Thomas C. and Tang, Yenzhi and Waldman, Adam D. and Quigley, Anne-Marie and Lewis, David and Soloviev, Dimtri and Nathan, Malavika and Bhogal, Pervinder and Jefferies, Sarah and Buscombe, John R.",
abstract = "There is increasing need for noninvasive biomarkers for glioma treatment-response evaluation and for distinguishing tumor progression and recurrence from treatment-related changes. Here, SPECT, particularly 201Tl SPECT, plays an important role. SPECT takes advantage of glioma
cellular make-up. Specifically, Na+/K+ pump expression, mitochondrial attenuation, and amino acid transporter expression are probed with 201Tl, 99mTc-MIBI, and 123IMT radiotracers respectively. 201Tl can be used to distinguish
brain tumors and nontumors and to determine brain tumor type and grade gliomas. However, it is especially valuable in the detection of tumor recurrence in patients treated with radiation therapy for supratentorial glioma. Similarly, 99mTc-MIBI can be used to distinguish recurrence
from treatment residua. 99mTc-TF is comparable with 99mTc-MIBI, and both may allow clear identification of tumor boundaries. 123IMT appears to be superior to 99mTc-MIBI in determining tumor recurrence and is particularly promising in detecting LGG
recurrence. Additionally, 123IMT shows promise in treatment planning where there is a survival advantage. LGGs frequently express somatostatin receptors; however, because radiolabeled somatostatin analogs do not cross the BBB and because LGGs frequently do not disturb the BBB, somatostatin-receptor
imaging is limited in glioma imaging. Among the non-natural amino acid class, 123IPA is not preferable to the more established 123IMT. In summary, most international experience by using SPECT is with 201Tl; however, other radiotracers are used with good effect
in some clinics.",
}